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Age-Dependent Changes of the Fcγ-Receptor-Mediated Functions of Human Monocytes
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1984
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AgingAge-dependent AlterationsImmunologyHealthy Young PeopleBlood CellImmune SystemImmune DysregulationInflammationFc Gamma ReceptorsHematologyAutoimmune DiseaseAllergyGranulocyteChronic InflammationAutoimmunityImmune FunctionCell BiologyHuman MonocytesPhagocyteCytokineMedicine
The age-dependent alterations of phagocytosis and age-dependent cell change (ADCC) activity through Fc gamma receptors of human monocyte monolayers using anti-D human IgG-coated 51Cr-labeled human red blood cells were determined. 40 healthy aged subjects of both sexes (age: 60-85 years) and 20 healthy young people of both sexes (age: 18-25 years) were studied. The phagocytosis increased significantly with aging in both sexes, whereas a decrease in ADCC activity was found.