Clinical Neuropharmacology · 2015 · 13 citations · 7 references
MedicinePharmacologyPsychiatryNeuropharmacologyNeuropsychiatryPsychopharmacologyAntipsychotic PharmacologyDopaminergic PharmacologyImpulse-control DisordersNeuropsychiatric DisordersParkinson DiseaseParkinsonian DisordersCompulsive DisordersCompulsive Drug UseCompulsive UseDopamine Receptor AgonistsImpulse ControlParkinson's Disease PharmacotherapyPathological GamblingPsychosis In Parkinson’s Disease
Impulse control disorders are frequent in Parkinson disease and are commonly associated with dopamine agonists intake. Typical manifestations include punding, hypersexuality, pathological gambling, and other compulsive behaviors. Symptoms often promptly disappear when dopamine agonists are discontinued, but if the origin is misinterpreted, symptoms may become a problem. We here report the case of a patient with juvenile Parkinson disease treated with 4.5 mg/d of pramipexol, who developed the need to adopt cats. He adopted almost 50 of them, but after he adopted them, he felt the need to kill them. The case became well known, and he became depressed and isolated. He was admitted to a psychiatric hospital and thought that he was a psychotic. However, when pramipexol was replaced by levodopa, the symptoms disappeared. This case illustrates the wide range of manifestations of impulse control disorders and warrants the inclusion of violent behaviors among them.
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Impulse Control Disorders in Parkinson Disease
Daniel Weintraub, Juergen Koester, Marc N. Potenza et al. · Archives of Neurology · 2010 · 1.5K citations
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Association of Dopamine Agonist Use With Impulse Control Disorders in Parkinson Disease
Daniel Weintraub, Andrew Siderowf, Marc N. Potenza et al. · Archives of Neurology · 2006 · 664 citations · Full text
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Impulse control disorders in parkinson disease: A multicenter case–control study
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Frank R. Ascione, Claudia V. Weber, Teresa M. Thompson et al. · Violence Against Women · 2007 · 264 citations