C−H Oxidative Addition with a (PCP)Ir(III)-Pincer Complex

Abstract

Treatment of 4-MeO-C 6 H 3 -2,6-(CH 2 P t Bu 2 ) 2 with IrCl 3 ·nH 2 O in i -PrOH/H 2 O gives a cyclometalated pincer chlorohydrido iridium complex. A second intramolecular oxidative addition reaction of one of the tert -butyl C−H bonds to the Ir(III) center followed by the reductive elimination of H 2 gives a novel doubly metalated compound that is stable to air and water. X-ray crystallographic analysis revealed a chelated square-pyramidal iridium compound with two cyclometalated five-membered rings in the basal plane and the iridium bound methylene group of the four-membered ring in the apical position. The free coordination site is protected by an agostic C−H bond. While a phosphorus−phosphorus coupling constant of 351.1 Hz establishes the trans position of the phosphorus groups there is no indication of a hydridic or weakly bound hydrogen. Electrochemical studies establish an equilibrium between the pincer chlorohydrido compound and the doubly metalated complex and H 2 . A square scheme can be used to describe the relationship between the redox couples and solution equilibria. The unusual stability of the doubly metalated complex was supported by DFT calculations at different levels of theory on model compounds. They show the coordination of two hydrogen atoms best described as η 2 -coordinated dihydrogen and suggest an Ir(V) oxidation state as intermediate.