Concepedia

Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second‐line medical therapy or surgery

Gwo‐Tzer Ho, Craig Mowat, CA Goddard, Jill Fennell, Neha Shah, R.J. Prescott, Jack Satsangi

Alimentary Pharmacology & Therapeutics · 2004 · 286 citations · 22 references

DOIFull text

Open access

Abstract

This risk score allows the early identification of patients with severe ulcerative colitis who would be suitable for second-line medical therapy or surgery.

References

22

Classification of Inflammatory Bowel Disease

J E Lennard‐Jones · Scandinavian Journal of Gastroenterology · 1989 · 2K citations

, , +12

Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy

Simon Lichtiger, D. H. Present, Asher Kornbluth et al. · New England Journal of Medicine · 1994 · 1.7K citations

The course and prognosis of ulcerative colitis: Part I Short-term prognosis

F Edwards, S. C. Truelove · Gut · 1963 · 860 citations · Full text

, , +9

Predicting outcome in severe ulcerative colitis.

Simon Travis, J. Mark Farrant, Christopher J. Ricketts et al. · Gut · 1996 · 768 citations · Full text

Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis1 1Gert Van Assche, Severine Vermeire, Geert D’Haens, and Paul Rutgeerts have been instrumental in the design of the study, trial management, data analysis, and writing the paper. Maja Noman had a major contribution in the clinical ambulatory follow-up of the patients in the trial. Martin Hiele followed cyclosporine levels and adjusted drug doses of patients in the trial and provided statistical advice. Katrien Asnong was the study coordinator and had a major share in data analysis. Joris Arts analyzed safety data and followed patients clinically during the trial. Andre D’Hoore and Freddy Penninckx performed the surgical interventions in patients failing the trial and substantially contributed in evaluating patients for colectomy.

Gert Van Assche, Geert D’Haens, Maja Noman et al. · Gastroenterology · 2003 · 445 citations