F2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: effects of vitamin E

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

Jason D. Morrow, Kristina E. Hill, Raymond F. Burk et al. · Proceedings of the National Academy of Sciences · 1990 · 1.9K citations

Life Sciences, Biochemistry, Pharmacology +9

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and <i>ob/ob</i> Mice and Zucker Fatty Rats

Toshihiko Fujiwara, Shinji Yoshioka, Takao Yoshioka et al. · Diabetes · 1988 · 455 citations

Medicine, Endocrinology, Pharmacology +17

Insulin and Obesity in the Zucker Genetically Obese Rat “Fatty”

Lois M. Zucker, Harry N. Antoniades · Endocrinology · 1972 · 420 citations

Medicine, Endocrinology, Physiology +17

Plasma 8‐epi‐PGF_2α levels are elevated in individuals with non‐insulin dependent diabetes mellitus

N.K. Gopaul, Erik Änggård, Anthony I. Mallet et al. · FEBS Letters · 1995 · 392 citations

Life Sciences, Biochemistry, Endocrinology +16

Elevated Levels of Authentic Plasma Hydroperoxides in NIDDM

Jaffar Nourooz‐Zadeh, Javad Tajaddini-Sarmadi, Sue McCarthy et al. · Diabetes · 1995 · 262 citations

Life Sciences, Biochemistry, Biochemical Pharmacology +16