HIV-1 reverse transcriptase inhibitory principles from Chamaesyce hyssopifolia

Abstract

In the course of our studies on the development of anti-acquired immunodeficiency syndrome (AIDS) agents, we isolated corilagin, quercetin 3-O -β-D-glucopyranoside and 1,3,4,6-tetra-O -galloyl-β-D-glucopyranose from Chamaesyce hyssopifolia, as the main inhibitory substances against human immunodeficiency virus (HIV) reverse transcriptase, an enzyme essential for the proliferation of HIV. The IC50 of these substances were 20, 50 and 86 μM, respectively, their modes of inhibition being non-competitive with respect to the substrate. © 1997 John Wiley & Sons, Ltd.