Concepedia

Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration

Huansheng Dong, M. Sunil Kumar, Yaoyu Zhang, Armen V. Gyulkhandanyan, Yun Xiang, Bai-Kang Ye, Joel Perrella, Ayman Hyder, Nanyi Zhang, Michael B. Wheeler,

Diabetologia · 2006 · 116 citations · 33 references

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33

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

Arnaud Merglen, Sten Theander, Gaelle Chaffard et al. · Endocrinology · 2003 · 584 citations · Full text

, , +17

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

Susan Bonner‐Weir, Lelio Orci · Diabetes · 1982 · 482 citations

, , +12

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

Patrik Rorsman, Per‐Olof Berggren, Krister Bokvist et al. · Nature · 1989 · 461 citations

, , +12

GABA and pancreatic beta‐cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic‐like microvesicles suggests their role in GABA storage and secretion.

Annette Reetz, Michele Solimena, Michela Matteoli et al. · The EMBO Journal · 1991 · 382 citations · Full text

, , +16

Insulin within islets is a physiologic glucagon release inhibitor.

Hiroshi Maruyama, Akitaka Hisatomi, Lelio Orci et al. · Journal of Clinical Investigation · 1984 · 296 citations · Full text

, , +15