An Efficient Domino Approach for the Synthesis of Multisubstituted Pyrroles <i>via</i> Gold/Silver‐Catalyzed Amination/Cycloisomerization of (<i>Z</i>)‐2‐En‐4‐yn‐1‐ols

Abstract

Abstract An efficient and one‐pot synthesis of multisubstituted pyrroles with high diversity and in a regioselective manner from the reactions of suitably substituted ( Z )‐enynols with amines or sulfonamides under mild reaction conditions has been developed. This synthesis was realized via a cascade process in the presence of gold/silver (Au/Ag) or boron trifluoride⋅etherate/gold/silver (BF 3 ⋅Et 2 O/Au/Ag) catalysts, which could catalyze amination and cycloisomerization reactions in the same vessel.