The European Journal of Surgery · 2002 · 15 citations · 8 references
MedicineHematologySurgeryBreast OncologyHemostasisVascular SurgeryAnticoagulant ManagementBreast SurgeryDeep Vein ThrombosisThromboembolism PreventionThrombosisThrombosis PreventionAnticoagulant-related Bleeding ComplicationsAnticoagulation-related Bleeding RiskBleedingHeparin AnticoagulationHeparin-induced ComplicationsLow-molecular-weight Heparin ProphylaxisLow-molecular-weight Heparin TherapyPerioperative Anticoagulant Management
Bleeding complications after excision of lumps in the breast are common and may be related to the prescription of heparin for prophylaxis of thrombo-embolism. Between I June 1997 and I January 2000, 206 lumps of the breast were removed in 186 patients. All patients received a low molecular weight heparin as a prophylaxis for deep venous thrombosis. The number of bleeding complications was 23 (11%). Patients operated on the day of admission had more bleeding complications than those who were operated on the day after admission (19/145 (13%) compared with 4/61 (7%)). The difference was not significant (p = 0.26). Smoking and use of antihypertensive medication were registered more often in patients without bleeding complications. Lumpectomy of the breast is an operation with a lot of bleeding complications. This might be related to the timing of deep venous thrombosis prophylaxis.
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H. Leon Pachter, Thomas S. Riles · Annals of Surgery · 1977 · 77 citations · Full text