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Myocardial Contractile Dysfunction Induced by Ovariectomy Requires AT<sub>1</sub>Receptor Activation in Female Rats

Rogério Faustino Ribeiro Júnior, Brunella M. M. Pavan, Felipe Fonseca Potratz, Jonaína Fiorim, Maylla Ronacher Simões, Fernanda Moura Vargas Dias, Filipe Lugon Moulin Lima, Aurélia Araújo Fernandes, Dalton Valentim Vassallo, Ivanita Stefanon

Cellular Physiology and Biochemistry · 2012 · 33 citations · 0 references

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Abstract

This study demonstrated that myocardial contractile dysfunction induced by ovariectomy and expression of key Ca(2+)-handling proteins were prevented by losartan treatment and that AT(1) receptor activation is involved in this response.