Catalysts · 2015 · 41 citations · 19 references
Natural SciencesChemical EngineeringChemistryAnalytical ChemistryCatalysisReaction EngineeringCatalyst PreparationCatalytic Reaction EngineeringCross-coupling ReactionsReaction Process DesignCross-coupling CatalysisFlow ChemistryFlow-based High-throughput SynthesisLeachingMethod Detection LimitPalladium CatalystsPalladium-catalyzed Cross-couplingSuzuki - Miyaura Coupling
The continuous flow Suzuki-Miyaura reaction between various haloarenes and arylboronic acids was successfully achieved within only ca. 20 s during the single-pass through a cartridge filled with palladium on carbon (Pd/C). No palladium leaching was observed in the collected reaction solution by atomic absorption spectrometry (detection limit: 1 ppm).
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