Copper‐Mediated Direct Cross‐Coupling of 1,3,4‐Oxadiazoles and Oxazoles with Terminal Alkynes

Abstract

The simplest coupling: Copper-mediated direct oxidative cross-coupling of 1,3,4-oxadiazoles and oxazoles with terminal alkynes proceeds through cleavage of sp2 CH and sp CH bonds to furnish the corresponding alkynylazoles in good yields. The reaction is tolerant toward various substitution patterns of substrates and allows the facile construction of azole-core π-conjugated systems.