Three LD (MLC) Determinants. A Danish Population Study

Abstract

During a search among offsprings of first cousin marriages three SD and LD homozygous individuals were found. They are supposed to define three alleles ‐ j, l and s ‐ at the major MLC locus. In a sample of 101 unrelated and healthy adult Danes, the gene frequency was found to be P(j) = 0.078, P(l) = 0.1225 and P(s) = 0.1460. Each of these genes was found to be strongly associated with one or two SD genes ‐ most often at the FOUR series ‐ and the degree of gametic association was similar to that of the SD haplotypes, HL‐A1,8 and HL‐A3,7. The allele j showed the strongest association with W5, while s showed association with HL‐A7 and l is associated with both HL‐A12 and W19. The reliability of the MLC typing was found to be sufficiently good for j and s while it was not so good for l. The reproducibility in J typings is better than 98 %.