Canadian Journal of Physiology and Pharmacology · 1979 · 15 citations · 0 references
PharmacyPharmacologyToxicologyDevelopmental ToxicologyPharmaceutical ToxicologyReproductive ToxicologyPerinatal PharmacologyPrenatal ToxicityReproductive PharmacologyDose-time RelationshipDrug-induced TeratogenesisDrug-induced TeratogenicityMechanisms Of TeratogenesisOral TreatmentPharmaceutical TeratogenicityPrenatal Drug ExposureTeratogenic Effects Of Drugs
Pregnant hamsters were treated with different doses of oral and intravenous diazepam during the period of organogenesis. Teratogenic effects of diazepam were observed following oral treatment on days 8 and 10 and following intravenous treatment on day 11 of gestation. Types of malformations included cleft palate, exencephaly, limb anomalies, and hemorrhage. A dose-effect relationship was not observed. Comparison with reported literature seems to indicate that diazepam may be a mild teratogen in some species.