Central and Peripheral Irisin Differentially Regulate Blood Pressure

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

Paul Lee, Joyce D. Linderman, Robert J. Brychta et al. · Cell Metabolism · 2014 · 806 citations · Full text

Life Sciences, Endocrinology, Physiology +13

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Yuan Zhang, Rui Li, Yan Meng et al. · Diabetes · 2013 · 729 citations · Full text

Life Sciences, Biochemistry, Physiology +16

The effects of acute and chronic exercise on <scp>PGC</scp>‐1α, irisin and browning of subcutaneous adipose tissue in humans

Frode Norheim, Torgrim M. Langleite, Marit Hjorth et al. · FEBS Journal · 2013 · 560 citations · Full text

Life Sciences, Endocrinology, Physiology +17

Effects of obesity, diabetes and exercise on <i>Fndc5</i> gene expression and irisin release in human skeletal muscle and adipose tissue: <i>in vivo</i> and <i>in vitro</i> studies

Tímea Kurdiová, Miroslav Baláž, M Vician et al. · The Journal of Physiology · 2013 · 398 citations · Full text

Medicine, Endocrinology, Physiology +17