Enkephalin regulates the levels of cyclic nucleotides in neuroblastoma × glioma hybrid cells

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

Eric J. Simon, Jacob M. Hiller, Irit Edelman · Proceedings of the National Academy of Sciences · 1973 · 1.1K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

Morphine receptors as regulators of adenylate cyclase activity.

S K Sharma, Marshall W. Nirenberg, Werner A. Klee · Proceedings of the National Academy of Sciences · 1975 · 531 citations · Full text

Medicine, Pharmacology, Molecular Pharmacology +16

An endogenous morphine-like factor in mammalian brain

Gavril W. Pasternak, Robert Goodman, Solomon H. Snyder · Life Sciences · 1975 · 393 citations

Life Sciences, Neurobiology, Neuroscience +14