International Journal of Oncology · 2000 · 64 citations · 4 references
MedicineMolecular GeneticsOncologyCancer GeneticsMolecular OncologyNeoplasiaBenign Parotid TumorsBenign Salivary Gland TumorsMalignant Parotid TumorsMalignant Salivary Gland TumorsSalivary Gland PathologySalivary GlandsBenign Salivary Gland LesionsMalignant Salivary Gland LesionsMalignant Salivary Gland NeoplasmsMutationParotid Pleomorphic AdenomaPleomorphic Adenoma CarcinomaSalivary Gland Tumor CytologySalivary Gland Tumor Diagnosis
The expression and mutation patterns of p53 were studied in a series of 68 benign pleomorphic adenomas and 237 malignant salivary gland tumors. p53 overexpression (nuclear staining exceeding 10%) was detected in 20% of the malignant salivary gland tumors, with the highest prevalence observed in polymorphous low grade adenocarcinoma, squamous cell carcinoma, and carcinoma ex pleomorphic adenoma and the lowest in adenoid cystic carcinoma and acinic cell carcinoma. In contrast, none of the 68 benign pleomorphic adenomas had nuclear staining exceeding 10%. SSCP and nucleotide sequence analysis of exons 4 to 9 of p53 in 19 malignant tumors revealed 9 mutations in 7 tumors. Our findings indicate that p53 may be a useful marker to help discriminate between benign and malignant salivary gland tumors.
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Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations
<i>p53</i>mutations in lung tumours: relationship to gender and lung DNA adduct levels
Elin H. Kure, David Ryberg, Alan Hewer et al. · Carcinogenesis · 1996 · 177 citations