Structure-activity Relationships of Cephalosporin Derivatives against Methicillin-resistant Staphylococcus aureus and Enterococcus faecalis.

Abstract

Over the past few years, a number of cephalosporin antibiotics having a broad spectrum and stability to /Mactamase have been developed1}. These drugs have a heterocyclic group at the C-3 position for broadspectrum activity and an alkoxyimino-aminothiazol group at the C-7 position for stability to /Mactamase.