Proceedings of the National Academy of Sciences · 2004 · 176 citations · 31 references
Brain DevelopmentNew NeuronsCamp-response-element-binding ProteinSocial SciencesNeuroinflammationAdult NeurogenesisNeuroregenerationNeurogenesisBrain InjuryNeurologyNeurochemistryMolecular NeuroscienceNeuroprotectionAdult Dentate GyrusCerebral Blood FlowDevelopmental BiologyNeurophysiologyNeuroanatomyNeuroscienceIschemia-induced NeurogenesisCentral Nervous SystemMolecular NeurobiologyMedicineNeural Stem Cell
New neurons are generated in adult mammalians and may contribute to repairing the brain after injury. Here, we show that the number of new neurons in the dentate gyrus of adult rats increased in cerebral ischemic stroke and correlated with activation of the cAMP-response-element-binding protein (CREB). Inhibition of endogenous CREB by expression of a dominant-negative mutant of CREB (CREB-S133A or CREB-R287L) blocked ischemia-induced neurogenesis in the dentate gyrus of adult rats, whereas expression of constitutively active CREB, VP16-CREB, increased the number of new neurons. Thus, our findings provide roles and regulatory mechanisms for CREB in adult neurogenesis and possibly suggest a practical strategy for replacing dead neurons in brain injury.
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