Effects of Anoxia at Birth on Central Nervous System of the Guinea Pig

Abstract

Anoxia induced at birth invariably produced symptoms of neural damage. Transient shock, tremors, ataxia, and incoördination were not usually associated with impaired behavior or brain pathology. More than 8 min of anoxia lead to such symptoms as decerebrate states, marked ataxia, convulsions, paralysis, hyper- and hypoesthesia and somnolence, correlated in some cases with behavioral changes. Highly variable nonspecific devastation of brain and cord tissues, occasional hemorrhages, gliosis and generalized atrophy were encountered.