2009 · 180 citations · 11 references
Life SciencesBiologySystems BiologyBiological Systems ModelingGene Regulatory NetworksNetwork BiologyBiological NetworksDynamic Network AnalysisNetwork DynamicsNetwork InferenceSocial Network AnalysisStochastic NetworksActorsEvolution Of Biological NetworksGene Network DynamicsGene Regulatory Network DynamicsInteraction Network DynamicsRegulatory Gene NetworksRegulatory Network ModelingVariational Bayesian Inference
In a dynamic social or biological environment, interactions between the underlying actors can undergo large and systematic changes. Each actor can assume multiple roles and their degrees of affiliation to these roles can also exhibit rich temporal phenomena. We propose a state space mixed membership stochastic blockmodel which can track across time the evolving roles of the actors. We also derive an efficient variational inference procedure for our model, and apply it to the Enron email networks, and rewiring gene regulatory networks of yeast. In both cases, our model reveals interesting dynamical roles of the actors.
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David M. Blei, John Lafferty · 2006 · 2.4K citations
Mixed Membership Stochastic Blockmodels.
Edoardo M. Airoldi, David M. Blei, Stephen E. Fienberg et al. · PubMed · 2008 · 1.5K citations · Full text
Genomic analysis of regulatory network dynamics reveals large topological changes
Nicholas M. Luscombe, M. Madan Babu, Haiyuan Yu et al. · Nature · 2004 · 994 citations
John Lafferty, David M. Blei · Neural Information Processing Systems · 2005 · 931 citations