DNA repair · 2009 · 151 citations · 27 references
Life SciencesCell BiologyMolecular BiologyDna RepairMolecular OncologyProtein-protein InteractionsProtein StructureRibosomal Rna-protein Interactions
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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations
Medicine, Oncology, Pharmacology +15
Mdm2 promotes the rapid degradation of p53
Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
Reiko Honda, Hirofumi Tanaka, Hideyo Yasuda · FEBS Letters · 1997 · 1.9K citations
Oncogenic forms of p53 inhibit p53-regulated gene expression
S E Kern, JA Pietenpol, Sam Thiagalingam et al. · Science · 1992 · 919 citations