Journal of Medicinal Chemistry · 1995 · 25 citations · 0 references
MedicineMedicinal ChemistryPharmacologyNeurochemistryNeuropharmacologyPsychopharmacologyAntipsychotic PharmacologyAntipsychotic PharmacotherapyAntipsychotic TherapyDopaminergic PharmacologyDopaminergic SignalingAntipsychotic ActionD2-like Dopamine ReceptorsDopamine D2-like ReceptorsDopamine Receptor AgonistsDopamine Receptor SubtypesImidazole Chemistry
A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. A 15-fold selectivity for cloned human D4 receptors over cloned African Green monkey D2 receptors was observed with 1-(2-pyridyl)-4-[[3-(1-phenylpyrrolyl)]methyl]piperazine.