Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia

Susan O’Brien, Hagop M. Kantarjian, Deborah A. Thomas, Jörge E. Cortes, Francis J. Giles, William G. Wierda, Charles Koller, Alessandra Ferrajoli, Mary Browning, Susan Lerner,

Cancer · 2003 · 222 citations · 15 references

DOIFull text

Open access

Abstract

Alemtuzumab produced significant responses in patients with residual disease after chemotherapy. Bone marrow disease was eradicated more frequently than lymph node disease, and molecular disease remissions were achieved. A randomized trial comparing alemtuzumab with observation after chemotherapy is indicated.

References

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