Elimination of Recombinant Hirudin by Modified Ultrafiltration During Simulated Cardiopulmonary Bypass: Assessment of Different Filter Systems

Abstract

Modified ultrafiltration may enhance the elimination of recombinant-hirudin, although plasmapheresis systems provide the most rapid and complete elimination of recombinant-hirudin during simulated cardiopulmonary bypass. The decision to use a specific system will ultimately depend on the prevailing clinical situation and overall health of the patient.