Cerebral Infarction in Alzheimer's Disease Is Associated With Severe Amyloid Angiopathy and Hypertension

Abstract

Severe AA is associated with an increased frequency of cerebral infarction in patients with AD. This appears to be largely due to an interaction between severe AA and hypertension that may produce multiplicative injuries on the vasculature. Further study with regard as to how AA may cause ischemia and its role in the neuropathologic and clinical progression of AD is needed.