A Versatile Approach for the Asymmetric Synthesis of 3‐Alkyl‐isoindolin‐1‐ones

Abstract

Abstract A flexible approach to ( R )‐3‐alkyl‐isoindolin‐1‐ones and ( R )‐3‐aryl‐isoindolin‐l‐ones via a diastereoselective reductive‐alkylation is described. Present method is versatile in scope, allowing the easy introduction of various C‐3 substituents by Grignard addition to phthalimide derived from ( R )‐phenylglycinol. 3‐Alkyl‐3‐hydroxy‐isoindolin‐1‐ones can also be obtained in the first step of the present method.