Chemical and Pharmaceutical Bulletin · 2003 · 12 citations · 23 references
Natural SciencesChemistryCatalysisOrganic ChemistryPolymer ChemistryAmino Acid ChemistryOrganic SynthesisPolymerization ChemistryRadical ReactionsSolid-phase SynthesisSupported CatalystsAmino Acid DerivativesControlled Radical PolymerizationFree Radical AdditionRadical Termination ReactionsRadical-radical ReactionsSolid-phase Stereoselective Synthesis
Stereocontrol in radical reactions of oxime ether anchored to polymer support was studied. Highly diastereoselective solid-phase radical reaction was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature, providing a novel method for the synthesis of the alpha-amino acid derivatives with excellent diastereoselectivities.
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