Chiral synthesis of lignan lactones, (–)-hinokinin, (–)-deoxypodorhizone, (–)-isohibalactone and (–)-savinin by means of enantioselective deprotonation strategy

Abstract

Chiral synthesis of lignan lactones, (–)-hinokinin, (–)-deoxypodorhizone, (–)-isohibalactone and (–)-savinin, has been achieved by employing an enantioselective deprotonation of 3-(3,4-methylenedioxybenzyl)cyclobutanone with lithium (S, S′)-α,α′-dimethyldibenzylamide, as a key step.