Organic Process Research & Development · 2004 · 13 citations · 9 references
HalogenationMedicinal ChemistryPractical SynthesisBioorganic ChemistryViable ProcessGuanidine BaseNatural SciencesPhosphorus OxychlorideOrganic ChemistryChemistryHeterocycle ChemistryPharmacologySynthetic ChemistryNatural Product Synthesis
A facile and industrially viable process for preparation of 2,6-dichloropurine is reported. The process involves direct chlorination of xanthine with phosphorus oxychloride and a weak nucleophilic organic base, such as amidine, guanidine base, or Proton-Sponge.
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