Concepedia

Total Syntheses of Eudistomins Y<sub>1</sub>–Y<sub>7</sub> by an Efficient One‐Pot Process of Tandem Benzylic Oxidation and Aromatization of 1‐Benzyl‐3,4‐dihydro‐β‐Carbolines

Tien Ha Trieu, Jing Dong, Qiang Zhang, Bo Zheng, Tian‐Zhuo Meng, Xia Lü, Xiao‐Xin Shi

European Journal of Organic Chemistry · 2013 · 25 citations · 18 references

DOI

Concepts

Abstract

Abstract The first total synthesis of eudistomin Y 7 ( 7 ) and total syntheses of eudistomins Y 1 –Y 6 ( 1 – 6 ) are described. An efficient room‐temperature conversion of 1‐benzyl‐3,4‐dihydro‐β‐carbolines ( 11 ) into 1‐benzoyl‐β‐carbolines ( 14 ) by a one‐pot process of tandem benzylic oxidation and aromatization as the key step of these total syntheses was also studied in detail.

References

18

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Eudistomins A, D, G, H, I, J, M, N, O, P, and Q, bromo, hydroxy, pyrrolyl and iminoazepino .beta.-carbolines from the antiviral Caribbean tunicate Eudistoma olivaceum

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