Magnetic Resonance, Pathology and Physiology of the BA1112 Rhabdomyosarcoma In Vivo

Abstract

Sostman D, Rockwell S, Smith GJW, Gore JC, Kennedy KA, Habib A, Fischer JJ, Armitage IM, Holcomb W. Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo. Invest Radiol 1988;23:277–288. We studied histology, findings on H-1 magnetic resonance (MR) imaging, and correlations of P-31 MR spectroscopy with microelectrode pH and pO2 measurements in the BA1112 rhabdomyosarcoma in WAG/Rij/Y rats. Intratumoral hemorrhage was a prominent feature on MR images and pathologic specimens. Eosinophilic necrosis could be seen microscopically but was not discernible on images. The peaks seen on P-31 MR spectra were similar to those reported in other tumors. The intratumoral pH was neutral despite low pO2 values and P-31 MR evidence for impaired metabolic status.