Detection of <i>Hp</i>^<i>del</i> among Thais, a deleted allele of the haptoglobin gene that causes congenital haptoglobin deficiency

Abstract

Congenital haptoglobin deficiency caused by Hp(del) homozygosity is presumed to be present in Thailand as a risk factor for anaphylactic transfusion reactions with a frequency similar to that in Japan. The causative deleted allele of the haptoglobin gene, Hp(del), is distributed among Southeast Asian populations as well as among Northeast Asian populations.