Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 464 citations

Life Sciences, Biochemistry, Chemistry +12

Irinotecan (CPT-11) High-Dose Escalation Using Intensive High-Dose Loperamide to Control Diarrhea

D Abigerges, P. Armand, G G Chabot et al. · JNCI Journal of the National Cancer Institute · 1994 · 245 citations

Medicine, Oncology, Pharmacology +15

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

Seigo Sawada, Satoru Okajima, Ritsuo Aiyama et al. · Chemical and Pharmaceutical Bulletin · 1991 · 233 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks.

Eric K. Rowinsky, L B Grochow, D S Ettinger et al. · PubMed · 1994 · 195 citations

Medicine, Oncology, Pharmacology +15

Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.

Masakiyo Hosokawa, Ryo Atsumi, Wataru Suzuki et al. · Biological and Pharmaceutical Bulletin · 1994 · 175 citations · Full text

Medicine, Biochemistry, Pharmacology +12