Recueil des Travaux Chimiques des Pays-Bas · 1975 · 20 citations · 1 references
Bioorganic ChemistryErythromycin AOrganic ChemistryAntimicrobial ChemotherapyChemical BiologyMedicinal ChemistryStructure Elucidation11,12‐Carbonate DerivativeA Cyclic CarbonateBiochemistryAntibacterial AgentAntimicrobial CompoundPharmacologyCyclic CarbonateHeterocyclicAntibioticsNatural SciencesMicrobiologyMedicine
Abstract The cyclic carbonate of erythromycin A, a compound with higher antibacterial activity than the parent antibiotic, is the 11,12‐carbonate derivative. The cyclic carbonate exhibits a hydroxy ketone/hemiacetal tautomerism in which the hemiacetal is the more stable form.
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