PubMed · 1989 · 192 citations · 0 references
Veterinary MedicinePathobiologyPhysiologyInflammationInnate ImmunityPulmonologyAcute InflammationAcute Lung InjuryInflammatory Cell ResponsesInflammatory PathologyNeutrophil BiologyPulmonary InflammationAcid Aspiration InjuryAcute Inflammatory InjuryAcute Inflammatory ResponseAcute Lung Injury PathophysiologyAspiration Lung InjuryLung Injury ModelingNeutrophil-mediated InjuryNeutrophil-mediated Lung Injury
The purpose of this study was to develop a reproducible model of acute acid aspiration-induced lung injury in the rat to explore the pathophysiology of aspiration pneumonitis. A biphasic injury pattern was observed with injury peaks at 1 hr and 4 hr. Histologic studies at 4 hr revealed significant increases in neutrophils in the alveolar interstitial space. These studies suggest that acid aspiration results in a biphasic acute injury. We hypothesize that the first phase results from a direct physiochemical process or is mediated via afferent (capsaicin sensitive) nerves or both. The second phase, occurring 2-3 hr later, is mediated by neutrophils and is consistent with an acute inflammatory response.