Mechanisms and kinetics of monoclonal antibody synthesis and secretion in synchronous and asynchronous hybridoma cell cultures

Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine.

Frank Dolbeare, Howard G. Gratzner, Maria G. Pallavicini et al. · Proceedings of the National Academy of Sciences · 1983 · 971 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH

William M. Miller, Harvey W. Blanch, C. R. Wilke · Biotechnology and Bioengineering · 1988 · 474 citations

Life Sciences, Biochemistry, Cell Biology +16

Factors affecting cell growth and monoclonal antibody production in stirred reactors

Shaul Reuveny, Daniel Uribe-Vélez, James D. Macmillan et al. · Journal of Immunological Methods · 1986 · 267 citations

Engineering, Biotechnology, Chemical Engineering +16

Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.

Kenneth W. Beagley, J H Eldridge, Hiroshi Kiyono et al. · The Journal of Immunology · 1988 · 239 citations

Life Sciences, Cell Biology, Immunology +13

Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates

Michael W. Glacken, E. Adema, Anthony J. Sinskey · Biotechnology and Bioengineering · 1988 · 186 citations

Life Sciences, Biochemistry, Cell Biology +16