Therapeutic Drug Monitoring · 1979 · 66 citations · 0 references
PharmacyClinical PharmacokineticsPharmacologyEpilepsyPharmacokinetic ModelingPopulation PharmacokineticsArea Under The CurveDose CalculationPediatric Drug DosingPharmacoepidemiologyPopulation Pharmacokinetic ModelingAntiepileptic Drug DosingBody Surface Area - Based DosingBody Surface Area CalculationDrug Half-life EstimationPhenytoin TherapyPopulation Pharmacokinetic InterpretationSerum Drug Concentration Measurement
The nomogram devised by Richens and Dunlop for predicting phenytoin dose has been tested in 127 residential epileptic patients, and the data obtained were used to prepare a revised version of the nomogram. In a further 78 patients, this new version was found to be superior to the original. The mean Km value was found to be 23.8 mumoles/liter. Km was independent of age and body surface area, but Dmax correlated positively with the latter two variables.