Cutaneous Low-Dose Radiation Increases Tissue Vascularity through Upregulation of Angiogenic and Vasculogenic Pathways

Abstract

In this study we demonstrate that local, low-dose IR upregulates angiogenic chemokines and results in progenitor cell mobilization to the systemic circulation. There is a resultant increase in the vascularity of the irradiated flap, suggesting that the pro-angiogenic effects of IR can be harnessed locally.