Proceedings of the National Academy of Sciences · 1992 · 60 citations · 34 references
MedicineNeurobiologyNeuroscienceDevelopmental NeuroscienceNeuroanatomySensory NeuroscienceCortical DevelopmentDevelopmental NeurophysiologyNeural DevelopmentSensory DevelopmentSensory System DevelopmentSomatosensory CortexAutomated Image AnalysisBarrel CortexCortical Circuit DevelopmentDevelopment Of Cortical CircuitsDevelopmental Cortical MaturationIntracortical ConnectivitySensory Cortex MappingSensory Map Formation
The processes underlying development, refinement, and retention of the intracortical connections critical for the function of the mammalian brain are unknown. Horseradish peroxidase-labeled fibers in mouse somatosensory barrel cortex, which is patterned like the whiskers on the contralateral face from which it receives inputs, were evaluated by automated image analysis. The sensory nerve to the whiskers was sectioned on postnatal day 7, after the whisker map is set. The deprived barrel cortices, examined in adults, showed drastically diminished intracortical projections relative to normal controls, although the map of the whiskers in the cortex was unchanged. This demonstrates anatomically that the normal pattern of intracortical connections, like the normal sensory map, is dependent upon the sensory periphery four synapses away.
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