Optimization of an Imidate Hydrolysis Reaction: Use of DOE and Mathematical Modeling to Deliver Yield and Productivity Improvements

Abstract

Experimental design and mathematical modeling techniques were used in the optimization of a Pinner quench process. The detailed effects of water, agitation, and temperature on both product yield and quality were elucidated. Significant improvements in both yield (5%) and throughput (>50%) were attained. This work demonstrates how the use of experimental design techniques in chemical process development adds value by allowing efficient optimization of a given synthetic step. The progress of the project from initial lab-scale investigations to full plant-scale implementation is described.