Formation of oxy radicals by oxygen reduction arising from the surface activity of asbestos

Abstract

Formation of hydroxyl radicals, in relatively large quantities, by oxygen reduction due to the surface activity of asbestos in a cell-free system is demonstrated, using electron spin resonance and a spin trapping agent. The quantity of OH • produced (in general, above 10 14 mg −1 for a Canadian chrysotile) is a function of activation or passivation of the electron donor surface sites of the minerals. The role of these radicals in oxidative stress in relation to the toxic properties of these minerals is discussed.