THE EFFECTS OF LONG‐TERM THERAPY WITH OESTRIOL UCCINATE ON THE HAEMOSTATIC MECHANISM IN OSTMENOPAUSAL WOMEN

Abstract

Summary In a previous report we showed that oestriol succinate administered to post‐menopausal women caused fewer changes in haemostatic function over a four‐month period than ethinyloestradiol. Potential longer‐term effects were studied in postmenopausal women treated for osteoporosis with oestriol succinate for up to 12 months. Over this period there was no significant change in concentration of plasma coagulation factors, an increase in plasminogen concentration and euglobulin lysis activity, and an inconsistent increase in platelet sensitivity to aggregation induced by ADP and collagen. The relative lack of effect of oestriol succinate on coagulation function is encouraging with regard to the future incidence of thromboembolic complications of therapy. We thank the Special Trustees of the General Infirmary, Leeds, for their financial support. Organon Laboratories Limited gave generous financial assistance and provided oestriol succinate tablets. We are grateful to Professor B. E. C. Nordin for allowing us to study patients under his care. Mrs G. Fieldhouse, Mrs B. Griffin, Mrs A. Spencer and Mr J. Leek gave valuable technical assistance.