Concepedia

Bioactive Saponins and Glycosides. X. On the Constituents of Zizyphi Spinosi Semen, the Seeds of Zizyphus jujuba MILL. var. spinosa HU (1): Structures and Histamine Release-Inhibitory Effect of Jujubosides A1 and C and Acetyljujuboside B.

Masayuki YOSHIKAWA, Toshiyuki Murakami, Akira IKEBATA, Shuji WAKAO, Nobutoshi Murakami, Hisashi Matsuda, Johji Yamahara

Chemical and Pharmaceutical Bulletin · 1997 · 67 citations · 0 references

Open access

Concepts

Life SciencesBotanyPharmacologyBiochemical PharmacologyPlant BiochemistryStructure-activity RelationshipsMedicinal Plant KnowledgeMedicinal PlantsActive Compound IsolationAnaphylactic Histamine ReleaseHistamine Release AssaysHistamine Release InhibitionHistamine Release MeasurementHistamine Release SuppressionPhysicochemical PropertiesSeed Phytochemical Content

Abstract

New dammarane-type triterpene oligoglycosides, jujubosides A1 and C and acetyljujuboside B1 were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba MILL. var. spinosa Hu, together-with three known saponins. The structures of jujubosides A1 and C and acetyljujuboside B were determined on the basis of chemical and physicochemical evidence. Jujubosides A1 and C and acetyljujuboside B were found to inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody-reaction.