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Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence

ThrombopoiesisThrombosisV617f Jak2Signal TransductionBlood PlateletReceptor Tyrosine KinaseHematologyImmunologyBlood CellAutoimmunityGrowth Factor IndependenceMedicineCell BiologyCell SignalingTyk2 MutationJak-stat Signaling Pathway