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Effect of Chinese Herbal Medicine “Saiko-Keishi-To” on Transmembrane Ionic Current of Snail Neurons
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1985
Year
Synaptic TransmissionAnesthetic MechanismTriangular CommandCellular PhysiologySocial SciencesHyperpolarization (Biology)Membrane TransportElectrolyte DisturbancePhytopharmacologyNeurochemistryTransmembrane Ionic CurrentMolecular PhysiologyChinese Herbal MedicineIon ChannelsNeuropharmacologyMembrane BiologyNervous SystemPharmacologySnail NeuronsNeurophysiologyPhysiologyElectrophysiologyVoltage ClampMedicine
The effect of the Chinese herbal medicine "Saiko-Keishi-To" (SK) on transmembrane ionic current was examined to elucidate the mechanism of the anticonvulsant action of SK. SK caused a decrease in tramsmembarane sodium, calcium and potassium current. SK was also found to inhibit the negative resistance characteristics in an experiment using a voltage clamp with triangular command.