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Effect of Stress on Circadian Periodicity in Serum LH and Prolactin Concentration
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1972
Year
Significant PeriodicityHomeostatic MechanismSerum LhReproductive EndocrinologyProlactin ConcentrationPituitary GlandCircadian RhythmSerum LevelsAnimal PhysiologyCircadian PeriodicitySleepStress HormoneEndocrine MechanismNon-stress LevelsEndocrinologyPharmacologyMelatoninCircadian BiologyPhysiologyMetabolismMedicineChronobiology
Non-stress levels of serum luteinizing hormone (LH), prolactin and corticosterone were determined at 3-hr intervals during controlled 24-hr light-dark cycles in adult male rats. Significant 24-hr periodicity was demonstrated for non-stress levels of serum LH, prolactin, and corticosterone; peak values for corticosterone, LH, and prolactin occurred at 5 PM, 8 PM and 11 PM respectively. In contrast, stress markedly reduced the amplitude in serum corticosterone and abolished the rhythm in serum LH concentrations; only serum prolactin showed significant periodicity following stress. These data suggest that circadian periodicity in serum levels of LH, prolactin, and corticosterone can be demonstrated for male rats provided adequate consideration is given to the effect of stress on adenohypophyseal function. (Endocrinology90: 29, 1972)