The Clinical Significance of Cytomegalovirus Infection in Renal Transplant Recipients

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Article1 June 1967The Clinical Significance of Cytomegalovirus Infection in Renal Transplant RecipientsDAVID RIFKIND, PH.D., M.D., NEAL GOODMAN, M.D., ROLLA B. HILL JR., M.D.DAVID RIFKIND, PH.D., M.D.Search for more papers by this author, NEAL GOODMAN, M.D.Search for more papers by this author, ROLLA B. HILL JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe high prevalence of cytomegalovirus infection after renal transplantation has been described in reports from the Harvard group (1, 2) and from this Center (3-9). In the present communication the cultural, serological, radiological, and pathological evidences for cytomegalovirus infection in the renal transplant patients treated here are correlated. This study defines some of the clinical consequences resulting from cytomegalovirus infection in these patients.MATERIALS AND METHODSVIRUS ISOLATIONIsolation of cytomegalovirus was accomplished in the WI-38 line of diploid human embryonic lung fibroblasts as described previously (7). Similar methods were used for varicella-zoster and herpes simplex viruses. The tissue culture...References1. HEDLEY-WHYTECRAIGHEAD ETJE: Generalized cytomegalic inclusion disease after renal homotransplantation. Report of a case with isolation of virus. New Eng. J. Med. 272: 473, 1965. CrossrefMedlineGoogle Scholar2. KANICHCRAIGHEAD REJE: Cytomegalovirus infection and cytomegalic inclusion disease in renal homotransplant recipients. Amer. J. Med. 40: 874, 1966. CrossrefMedlineGoogle Scholar3. RIFKINDSTARZLMARCHIOROWADDELLROWLANDSHILL DTETLWRDTRB: Transplantation pneumonia. JAMA 189: 808, 1964. CrossrefMedlineGoogle Scholar4. 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DE WARDENER, M.D., F.R.C.P.Infectious diseases. Annual review of significant publications.The Future of Vaccines Against Viral Diseases 1 June 1967Volume 66, Issue 6Page: 1116-1128KeywordsCytomegalovirus infectionHerpes simplexLungsMedical servicesPathogenesisPneumoniaRenal transplantationResearch fundingTissue culturesTransplantation ePublished: 1 December 2008 Issue Published: 1 June 1967 PDF downloadLoading ...