Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

Michael J. Kuhar, Candace B. Pert, Solomon H. Snyder · Nature · 1973 · 818 citations

Medicine, Neurobiology, Neuroscience +9

Analgesia from Electrical Stimulation in the Brainstem of the Rat

David J. Mayer, Thomas L. Wolfle, Huda Akil et al. · Science · 1971 · 763 citations

Life Sciences, Neurobiology, Neuroscience +16

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

David J. Mayer, John C. Liebeskind · Brain Research · 1974 · 717 citations

Life Sciences, Neurology, Neuroscience +16

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

Huda Akil, David J. Mayer, John C. Liebeskind · Science · 1976 · 669 citations

Medicine, Neurobiology, Pharmacology +17