Chemical Communications · 2012 · 37 citations · 16 references
Life SciencesBiochemistryMolecular BiologyEnzyme MechanismEnzymologyRedox BiochemistryCatalytic MechanismsCytochrome P450 EnzymesCytochrome P450-mediated MetabolismElectron Transfer In ProteinsRedox EnzymesRedox MetabolismCytochrome EnzymesCytochrome P450 Enzyme ActivityCytochrome P450 IsoenzymesCytochrome P450 MonooxygenasesElectron TransferEnzymesOxidationSubstrate Oxidation
A ferredoxin associated with biological Fe-S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the possibility of tailoring ferredoxins to reconstitute the activity of P450 enzymes for which the electron transfer partner proteins are not known.
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